Many high performance motors come with synthetic oil from the factory. The biggest concern would be putting a synthetic oil in an engine with high miles that was designed for and has been using conventional oil. You may see some oil burning issues in that case, but sythetic oil has a higher flash point than conventional, so it shouldn't be a big deal. When synthetic is recomended by the manufacturer, like with BMW, synthetic is used from the time the motor is new. Most synthetics aren't true synthetics anyway. Many of them are just highly refined conventional oils that behave like synthetics. Mobil 1 is an example, but Castrol Syntec was the first "synthetic" oil to use Class III conventional oils as a base.
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